Article
Genetic variation of TP53, polycyclic aromatic hydrocarbon-related exposures, and breast cancer risk among women on Long Island, New York.
Breast cancer research and treatment - 1 Mar 2008
Gaudet Mia M, Gammon Marilie D, Bensen Jeannette T, Sagiv Sharon K, Shantakumar Sumitra, Teitelbaum Susan L, Eng Sybil M, Neugut Alfred I, Santella Regina M
Abstract excerpt
BACKGROUND: p53 participates in cell cycle control, programmed cell death/apoptosis, and DNA repair, all pathways involved in carcinogenesis. TP53 variants may influence p53 function. OBJECTIVES: We evaluated whether three well-characterized TP53 variants -- Ex4 + 119 C > G (rs#1042522, Arg72Pro)...
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