Article
Polycyclic aromatic hydrocarbon and its adducts in peripheral blood: Gene and environment interaction among Chinese population.
Environment international - 1 Aug 2024
Guo Ling, Zhang Xuewei, Li Xinwei, Wang Kai, Wang Yanhua, Abulikemu Alimire, Su Xizi, Shu Mushui, Li Haibin, Cui Shiwei, Xu Zhizhen, Tian Haoyuan, Niu Yong, Yuan Huige, He Zhizhou, Sun Xin, Duan Huawei
Abstract excerpt
BACKGROUND: Benzo(a)pyrene (B[a]P) is the most widely concerned polycyclic aromatic hydrocarbons (PAHs), which metabolizes benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) in vivo to produce carcinogenic effect on the body. Currently, there is limited research on the role of the variation of metabolic enzymes in this process. METHODS: We carried out a study including 752 participants, measured the...
Topics
- Adult
- Female
- Humans
- Male
- Middle Aged
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- China
- Cytochrome P-450 CYP1A1
- DNA Adducts
- East Asian People