Article
Whole exome sequencing identifies lncRNA GAS8-AS1 and LPAR4 as novel papillary thyroid carcinoma driver alternations.
Human molecular genetics - 1 May 2016
Pan Wenting, Zhou Liqing, Ge Minghua, Zhang Bin, Yang Xinyu, Xiong Xiangyu, Fu Guobin, Zhang Jian, Nie Xilin, Li Hongmin, Tang Xiaohu, Wei Jinyu, Shao Mingming, Zheng Jian, Yuan Qipeng, Tan Wen, Wu Chen, Yang Ming, Lin Dongxin
Abstract excerpt
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. However, we know little of mutational spectrum in the Chinese population. Thus, here we report the identification of somatic mutations for Chinese PTC using 402 tumor-normal pairs (Discovery: 91 pairs via exome sequencing; validation: 311 pairs via Sanger sequencing). We observed three distinct mutational signatures, evidently different...
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