Identification of Long Noncoding RNAs Deregulated in Papillary Thyroid Cancer and Correlated with BRAFV600E Mutation by Bioinformatics Integrative Analysis.

doi:10.1038/s41598-017-01957-0

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Article

Identification of Long Noncoding RNAs Deregulated in Papillary Thyroid Cancer and Correlated with BRAFV600E Mutation by Bioinformatics Integrative Analysis.

Scientific reports - 10 May 2017

Goedert Lucas, Plaça Jessica Rodrigues, Fuziwara Cesar Seigi, Machado Maiaro Cabral Rosa, Plaça Desirée Rodrigues, Almeida Palloma Porto, Sanches Talita Perez, Santos Jair Figueredo Dos, Corveloni Amanda Cristina, Pereira Illy Enne Gomes, de Castro Marcela Motta, Kimura Edna Teruko, Silva Wilson Araújo, Espreafico Enilza Maria

Abstract excerpt

Papillary Thyroid Cancer (PTC) is an endocrine malignancy in which BRAFV600E oncogenic mutation induces the most aggressive phenotype. In this way, considering that lncRNAs are arising as key players in oncogenesis, it is of high interest the identification of BRAFV600E-associated long noncoding RNAs, which can provide possible candidates for secondary mechanisms of BRAF-induced malignancy in PTC. In this study,...

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PMID: 28490781
DOI: 10.1038/s41598-017-01957-0
PMCID: PMC5431778

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BRAF

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