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Article

Targeted next generation sequencing identifies somatic mutations and gene fusions in papillary thyroid carcinoma.

Oncotarget - 11 Jul 2017

Lu Zheming, Zhang Yujie, Feng Dongdong, Sheng Jindong, Yang Wenjun, Liu Baoguo

Abstract excerpt

138 papillary thyroid carcinoma (PTC) samples were assessed for somatic mutation profile and fusion genes by targeted resequencing using a cancer panel (ThyGenCapTM) targeting 244 cancer-related genes and 20 potential fusion genes. At least one genetic alteration (including mutations and fusion genes) was observed in 118/138 (85.5%) samples. The most frequently mutated gene was BRAF V600E (57.2%). Moreover, we...

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Share to Carcinoma, Papillary
Share to Mitogen-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neoplasm Grading

Share to Neoplasm Metastasis

Share to Proto-Oncogene Proteins B-raf

Share to Thyroid Cancer, Papillary

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Share to Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 28507274
DOI: 10.18632/oncotarget.17412
PMCID: PMC5542227

Genes

BRAF
NTRK3
OSBPL9
RET
SQSTM1
UEVLD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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