Article
Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons.
Neuron - 18 Jul 2002
Tobin David M, Madsen David M, Kahn-Kirby Amanda, Peckol Erin L, Moulder Gary, Barstead Robert, Maricq Andres V, Bargmann Cornelia I
Abstract excerpt
C. elegans OSM-9 is a TRPV channel protein involved in sensory transduction and adaptation. Here, we show that distinct sensory functions arise from different combinations of OSM-9 and related OCR TRPV proteins. Both OSM-9 and OCR-2 are essential for several forms of sensory transduction, including olfaction, osmosensation, mechanosensation, and chemosensation. In neurons that express both OSM-9 and OCR-2, tagged...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Behavior, Animal
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Capsaicin
- Cell Compartmentation
- Cell Membrane
- Gene Expression Regulation
- Ion Channels
- Molecular Sequence Data
- Mutation