Article
Foxg1 suppresses early cortical cell fate.
Science (New York, N.Y.) - 2 Jan 2004
Hanashima Carina, Li Suzanne C, Shen Lijian, Lai Eseng, Fishell Gord
Abstract excerpt
During mammalian cerebral corticogenesis, progenitor cells become progressively restricted in the types of neurons they can produce. The molecular mechanism that determines earlier versus later born neuron fate is unknown. We demonstrate here that the generation of the earliest born neurons, the Cajal-Retzius cells, is suppressed by the telencephalic transcription factor Foxg1. In Foxg1 null mutants, we observed...
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