Article
Ntf3 acts downstream of Sip1 in cortical postmitotic neurons to control progenitor cell fate through feedback signaling.
Development (Cambridge, England) - 1 Sept 2014
Parthasarathy Srinivas, Srivatsa Swathi, Nityanandam Anjana, Tarabykin Victor
Abstract excerpt
Cortical progenitors undergo progressive fate restriction, thereby sequentially producing the different layers of the neocortex. However, how these progenitors precisely change their fate remains highly debatable. We have previously shown the existence of cortical feedback mechanisms wherein postmitotic neurons signal back to the progenitors and promote a switch from neurogenesis to gliogenesis. We showed that...
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