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Article

NPAS1 represses the generation of specific subtypes of cortical interneurons.

Neuron - 3 Dec 2014

Stanco Amelia, Pla Ramón, Vogt Daniel, Chen Yiran, Mandal Shyamali, Walker Jamie, Hunt Robert F, Lindtner Susan, Erdman Carolyn A, Pieper Andrew A, Hamilton Steven P, Xu Duan, Baraban Scott C, Rubenstein John L R

Abstract excerpt

Little is known about genetic mechanisms that regulate the ratio of cortical excitatory and inhibitory neurons. We show that NPAS1 and NPAS3 transcription factors (TFs) are expressed in progenitor domains of the mouse basal ganglia (subpallium, MGE, and CGE). NPAS1(-/-) mutants had increased proliferation, ERK signaling, and expression of Arx in the MGE and CGE. NPAS1(-/-) mutants also had increased neocortical...

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Identifiers

PMID: 25467980
DOI: 10.1016/j.neuron.2014.10.040
PMCID: PMC4258152

Genes

NPAS1
NPAS3
SST
VIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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