Article

The neocortical progenitor specification program is established through combined modulation of SHH and FGF signaling

2019-11-14

Abstract excerpt

<h4>ABSTRACT</h4> Neuronal progenitors in the developing forebrain undergo dynamic competence states to ensure timely generation of specific excitatory and inhibitory neuronal subtypes from distinct neurogenic niches of the dorsal and ventral forebrain, respectively. Here we show evidence of progenitor plasticity when Sonic hedgehog (SHH) signaling is left unmodulated in the embryonic neocortex of the dorsal fore...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 25e5460e-184b-5445-847b-302cdc2e4154
DOI: 10.1101/841932

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The neocortical progenitor specification program is established through combined modulation of SHH and FGF signalingDOI 10.1101/841932Read

Hedgehog Signaling in Cortical DevelopmentSemantic proximity Read

Mapping the temporal and functional landscape of Sonic Hedgehog signaling reveals new insights into early human forebrain developmentSemantic proximity Read

Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.Semantic proximity Read

Molecular signatures and lineage diversification of neurogenic and gliogenic radial glia in the gyrencephalic ferret cortexSemantic proximity Read

Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling.Semantic proximity Read

A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo.Semantic proximity Read

The protooncogene Ski regulates the neuron-glia switch during development of the mammalian cerebral cortexSemantic proximity Read

Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation.Semantic proximity Read

The sonic hedgehog-GLI1 signaling pathway in brain tumor developmentSemantic proximity Read

Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain.Semantic proximity Read

Signal requirement for cortical potential of transplantable human neuroepithelial stem cellsSemantic proximity Read

Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development.Semantic proximity Read