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Article

The Human Cytomegalovirus UL116 Gene Encodes an Envelope Glycoprotein Forming a Complex with gH Independently from gL.

Journal of virology - 15 May 2016

Caló Stefano, Cortese Mirko, Ciferri Claudio, Bruno Luca, Gerrein Rachel, Benucci Barbara, Monda Giuseppina, Gentile Michela, Kessler Tobias, Uematsu Yasushi, Maione Domenico, Lilja Anders E, Carfí Andrea, Merola Marcello

Abstract excerpt

UNLABELLED: Human cytomegalovirus (HCMV) is a major cause of morbidity and mortality in transplant patients and is the leading viral cause of birth defects after congenital infection. HCMV infection relies on the recognition of cell-specific receptors by one of the viral envelope glycoprotein complexes. Either the gH/gL/gO or the gH/gL/UL128/UL130/UL131A (Pentamer) complex has been found to fulfill this role,...

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Source

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Identifiers

PMID: 26937030
DOI: 10.1128/JVI.02517-15
PMCID: PMC4859709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Human Cytomegalovirus UL116 Gene Encodes an Envelope Glycoprotein Forming a Complex with gH Independently from gL.PMID 26937030Read ↗

The human cytomegalovirus UL116 glycoprotein is a chaperone to control gH-based complexes levels on virionsSemantic proximity Read ↗

Human Cytomegalovirus gH/gL Forms a Stable Complex with the Fusion Protein gB in VirionsSemantic proximity Read ↗

Structural and biochemical studies of HCMV gH/gL/gO and Pentamer reveal mutually exclusive cell entry complexes.Semantic proximity Read ↗

Mutagenesis of human cytomegalovirus glycoprotein L disproportionately disrupts gH/gL/gO over gH/gL/pUL128-131Semantic proximity Read ↗

Characterization of the Human Cytomegalovirus gH/gL/UL128-131 Complex That Mediates Entry into Epithelial and Endothelial CellsSemantic proximity Read ↗

A dual role in virion attachment and entry makes the human cytomegalovirus gHgLgO trimer the central player in virion infectivitySemantic proximity Read ↗

Mutagenesis of Human Cytomegalovirus Glycoprotein L Disproportionately Disrupts gH/gL/gO over gH/gL/pUL128-131.Semantic proximity Read ↗

Comparative analysis of gO isoforms reveals that strains of human cytomegalovirus differ in the ratio of gH/gL/gO and gH/gL/UL128-131 in the virion envelope.Semantic proximity Read ↗

Human Cytomegalovirus gH/gL/gO Promotes the Fusion Step of Entry into All Cell Types, whereas gH/gL/UL128-131 Broadens Virus Tropism through a Distinct Mechanism.Semantic proximity Read ↗

Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodiesSemantic proximity Read ↗

Human Cytomegalovirus Vaccine Based on the Envelope gH/gL Pentamer ComplexSemantic proximity Read ↗

Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodiesSemantic proximity Read ↗

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