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Human Cytomegalovirus Vaccine Based on the Envelope gH/gL Pentamer Complex

20 Nov 2014

Abstract excerpt

Human Cytomegalovirus (HCMV) utilizes two different pathways for host cell entry. HCMV entry into fibroblasts requires glycoproteins gB and gH/gL, whereas HCMV entry into epithelial and endothelial cells (EC) requires an additional complex composed of gH, gL, UL128, UL130, and UL131A, referred to as the gH/gL-pentamer complex (gH/gL-PC). While there are no established correlates of protection against HCMV,...

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PMID: 25412505
DOI: 10.1371/journal.ppat.1004524

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