Article
Filaggrin-null mutations are associated with increased maturation markers on Langerhans cells.
The Journal of allergy and clinical immunology - 1 Aug 2016
Leitch Claire S, Natafji Eenass, Yu Cunjing, Abdul-Ghaffar Sharizan, Madarasingha Nayani, Venables Zoë C, Chu Roland, Fitch Paul M, Muinonen-Martin Andrew J, Campbell Linda E, McLean W H Irwin, Schwarze Jürgen, Howie Sarah E M, Weller Richard B
Abstract excerpt
BACKGROUND: Mutations in the gene encoding filaggrin (FLG), an epidermal structural protein, are the strongest risk factor identified for the development of atopic dermatitis (AD). Up to 50% of patients with moderate-to-severe AD in European populations have FLG-null alleles compared with a general population frequency of 7% to 10%. OBJECTIVE: This study aimed to investigate the relationship between FLG-null...
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