Article
Accumulating evidence for a role of TCF7L2 variants in bipolar disorder with elevated body mass index.
Bipolar disorders - 1 Mar 2016
Cuellar-Barboza Alfredo B, Winham Stacey J, McElroy Susan L, Geske Jennifer R, Jenkins Gregory D, Colby Colin L, Prieto Miguel L, Ryu Euijung, Cunningham Julie M, Frye Mark A, Biernacka Joanna M
Abstract excerpt
OBJECTIVES: Bipolar disorder (BD) is a complex disease associated with various hereditary traits, including a higher body mass index (BMI). In a prior genome-wide association study, we found that BMI modified the association of rs12772424 - a common variant in the gene encoding transcription factor 7-like 2 (TCF7L2) - with risk for BD. TCF7L2 is a transcription factor in the canonical Wnt pathway, involved in...
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