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Article

TCF7L2 lncRNA: a link between bipolar disorder and body mass index through glucocorticoid signaling.

Molecular psychiatry - 1 Dec 2021

Liu Duan, Nguyen Thanh Thanh Le, Gao Huanyao, Huang Huaizhi, Kim Daniel C, Sharp Brenna, Ye Zhenqing, Lee Jeong-Heon, Coombes Brandon J, Ordog Tamas, Wang Liewei, Biernacka Joanna M, Frye Mark A, Weinshilboum Richard M

Abstract excerpt

Bipolar disorder (BD) and obesity are highly comorbid. We previously performed a genome-wide association study (GWAS) for BD risk accounting for the effect of body mass index (BMI), which identified a genome-wide significant single-nucleotide polymorphism (SNP) in the gene encoding the transcription factor 7 like 2 (TCF7L2). However, the molecular function of TCF7L2 in the central nervous system (CNS) and its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34535768
DOI: 10.1038/s41380-021-01274-z
PMCID: PMC8872993

Genes

TCF7L2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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TCF7L2 lncRNA: a link between bipolar disorder and body mass index through glucocorticoid signaling.PMID 34535768Read ↗

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