Article
Genetic Polymorphisms in miR-137 and Its Target Genes, TCF4 and CACNA1C, Contribute to the Risk of Bipolar Disorder: A Preliminary Case-Control Study and Bioinformatics Analysis.
Disease markers - 1 Jan 2022
Mokhtari Mohammad Ali, Sargazi Saman, Saravani Ramin, Heidari Nia Milad, Mirinejad Shekoufeh, Hadzsiev Kinga, Bene Judit, Shakiba Mansoor
Abstract excerpt
Accumulating evidence has suggested that miR-137 and its target genes, CACNA1C, and TCF4, are amongst the most robustly implicated genes in psychiatric disorders. This preliminary study is aimed at investigating the effects of genetic variations in miR-137 (rs1625579A/C), TCF4 (rs1261084C/T), and CACNA1C (rs10774053A/G and rs10466907G/T) on BD susceptibility. We recruited 252 BD patients and 213 healthy subjects...
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