Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acquisition of NOTCH dependence is a hallmark of human intestinal stem cell maturation

7 Apr 2022

Abstract excerpt

NOTCH signaling is a key regulator involved in maintaining intestinal stem cell (ISC) homeostasis and for balancing differentiation. Using single-cell transcriptomics, we observed that OLFM4, a NOTCH target gene present in ISCs, is first expressed at 13 weeks post-conception in the developing human intestine and increases over time. This led us to hypothesize that the requirement for NOTCH signaling is acquired...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Digestive system and related health
Share to Renal and related cancers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35395175
DOI: 10.1016/j.stemcr.2022.03.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acquisition of NOTCH dependence is a hallmark of human intestinal stem cell maturationPMID 35395175Read ↗

An organoid and multi-organ developmental cell atlas reveals multilineage fate specification in the human intestineSemantic proximity Read ↗

Unraveling Enteroendocrine Cell lineage dynamics and associated gene regulatory networks during intestinal developmentSemantic proximity Read ↗

Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In VivoSemantic proximity Read ↗

A Development-Inspired Niche for Homeostatic Human Mini-IntestinesSemantic proximity Read ↗

The Transcription Co-Repressors MTG8 and MTG16 Regulate Exit of Intestinal Stem Cells From Their Niche and Differentiation Into Enterocyte vs Secretory LineagesSemantic proximity Read ↗

A proximal-to-distal survey of healthy adult human small intestine and colon epithelium by single-cell transcriptomicsSemantic proximity Read ↗

Single-cell sequencing of developing human gut reveals transcriptional links to childhood Crohn’s diseaseSemantic proximity Read ↗

Maturation of human intestinal epithelium from pluripotency <i>in vitro</i>Semantic proximity Read ↗

Infant and Adult Human Intestinal Enteroids are Morphologically and Functionally DistinctSemantic proximity Read ↗

EPIREGULIN creates a developmental niche for spatially organized human intestinal enteroidsSemantic proximity Read ↗

<i>In vitro</i> and <i>in vivo</i> development of the human intestinal niche at single cell resolutionSemantic proximity Read ↗

Infant and adult human intestinal enteroids are morphologically and functionally distinctSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.