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NOTCH1 and NOTCH2 regulate epithelial cell proliferation in mouse and human gastric corpus

8 Dec 2016

Abstract excerpt

The Notch signaling pathway is known to regulate stem cells and epithelial cell homeostasis in gastrointestinal tissues; however, Notch function in the corpus region of the stomach is poorly understood. In this study we examined the consequences of Notch inhibition and activation on cellular proliferation and differentiation and defined the specific Notch receptors functioning in the mouse and human corpus. Notch...

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Identifiers

PMID: 27932500
DOI: 10.1152/ajpgi.00325.2016

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