Article
Integrated analyses of gene expression and genetic association studies in a founder population.
Human molecular genetics - 15 May 2016
Cusanovich Darren A, Caliskan Minal, Billstrand Christine, Michelini Katelyn, Chavarria Claudia, De Leon Sherryl, Mitrano Amy, Lewellyn Noah, Elias Jack A, Chupp Geoffrey L, Lang Roberto M, Shah Sanjiv J, Decara Jeanne M, Gilad Yoav, Ober Carole
Abstract excerpt
Genome-wide association studies (GWASs) have become a standard tool for dissecting genetic contributions to disease risk. However, these studies typically require extraordinarily large sample sizes to be adequately powered. Strategies that incorporate functional information alongside genetic associations have proved successful in increasing GWAS power. Following this paradigm, we present the results of 20...
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