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Is toxicity of PMMA (paramethoxymethamphetamine) associated with cytochrome P450 pharmacogenetics?

Forensic science international - 1 Apr 2016

Vevelstad Merete, Øiestad Elisabeth Leere, Bremer Sara, Bogen Inger Lise, Zackrisson Anna-Lena, Arnestad Marianne

Abstract excerpt

In 2010-2013, 29 fatal intoxications related to the designer drug paramethoxymethamphetamine (PMMA, 4-methoxymethamphetamine) occurred in Norway. The current knowledge about metabolism and toxicity of PMMA in humans is limited. Metabolism by the polymorphic cytochrome P450 (CYP) 2D6 enzyme to the psychoactive metabolite 4-hydroxymethamphetamine (OH-MA), and possibly by additional enzymes, is suggested to be...

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PMID: 26930544
DOI: 10.1016/j.forsciint.2016.02.027

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