Article
Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes.
Nature genetics - 1 Jun 2011
Engelen Erik, Akinci Umut, Bryne Jan Christian, Hou Jun, Gontan Cristina, Moen Maaike, Szumska Dorota, Kockx Christel, van Ijcken Wilfred, Dekkers Dick H W, Demmers Jeroen, Rijkers Erik-Jan, Bhattacharya Shoumo, Philipsen Sjaak, Pevny Larysa H, Grosveld Frank G, Rottier Robbert J, Lenhard Boris, Poot Raymond A
Abstract excerpt
The HMG-box transcription factor Sox2 plays a role throughout neurogenesis and also acts at other stages of development, as illustrated by the multiple organs affected in the anophthalmia syndrome caused by SOX2 mutations. Here we combined proteomic and genomic approaches to characterize gene regulation by Sox2 in neural stem cells. Chd7, a chromatin remodeling ATPase associated with CHARGE syndrome, was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.