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Article

Molecular analyses of circadian gene variants reveal sex-dependent links between depression and clocks.

Translational psychiatry - 1 Mar 2016

Shi S-q, White M J, Borsetti H M, Pendergast J S, Hida A, Ciarleglio C M, de Verteuil P A, Cadar A G, Cala C, McMahon D G, Shelton R C, Williams S M, Johnson C H

Abstract excerpt

An extensive literature links circadian irregularities and/or sleep abnormalities to mood disorders. Despite the strong genetic component underlying many mood disorders, however, previous genetic associations between circadian clock gene variants and major depressive disorder (MDD) have been weak. We applied a combined molecular/functional and genetic association approach to circadian gene polymorphisms in...

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Identifiers

PMID: 26926884
DOI: 10.1038/tp.2016.9
PMCID: PMC4872462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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