Circadian depression: A mood disorder phenotype.

doi:10.1016/j.neubiorev.2021.02.045

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Article

Circadian depression: A mood disorder phenotype.

Neuroscience and biobehavioral reviews - 1 Jul 2021

Carpenter Joanne S, Crouse Jacob J, Scott Elizabeth M, Naismith Sharon L, Wilson Chloe, Scott Jan, Merikangas Kathleen R, Hickie Ian B

Abstract excerpt

Major mood syndromes are among the most common and disabling mental disorders. However, a lack of clear delineation of their underlying pathophysiological mechanisms is a major barrier to prevention and optimised treatments. Dysfunction of the 24-h circadian system is a candidate mechanism that has genetic, behavioural, and neurobiological links to mood syndromes. Here, we outline evidence for a new clinical...

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PMID: 33689801
DOI: 10.1016/j.neubiorev.2021.02.045

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