Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.

doi:10.1038/npp.2009.230

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Article

Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2010

Soria Virginia, Martínez-Amorós Erika, Escaramís Geòrgia, Valero Joaquín, Pérez-Egea Rosario, García Cecilia, Gutiérrez-Zotes Alfonso, Puigdemont Dolors, Bayés Mònica, Crespo José M, Martorell Lourdes, Vilella Elisabet, Labad Antonio, Vallejo Julio, Pérez Víctor, Menchón José M, Estivill Xavier, Gratacòs Mònica, Urretavizcaya Mikel

Abstract excerpt

Disruptions in circadian rhythms have been described in mood disorders (MD), but the involvement of genetic variation in genes pertaining to the molecular circadian machinery in the susceptibility to MD has not been conclusively determined. We examined 209 single-nucleotide polymorphisms (SNPs) covering 19 circadian genes (ADCYAP1, ARNTL, ARNTL2, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1E, DBP, NPAS2, NR1D1, PER1,...

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