Clock gene polygenic risk score and seasonality in major depressive disorder and bipolar disorder.

doi:10.1111/gbb.12683

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Article

Clock gene polygenic risk score and seasonality in major depressive disorder and bipolar disorder.

Genes, brain, and behavior - 1 Nov 2020

Ferrer Alex, Costas Javier, Gratacos Mònica, Martínez-Amorós Èrika, Labad Javier, Soriano-Mas Carles, Palao Diego, Menchón Jose Manuel, Crespo Jose Manuel, Urretavizcaya Mikel, Soria Virginia

Abstract excerpt

Seasonal changes in mood and diurnal preference are two well-characterized chronobiological phenotypes in major depressive disorder (MDD) and bipolar disorder (BD). The biological mechanisms regulating physiological changes related to seasonality and chronotype involve several genes known as "clock" or circadian genes. Our goal was to study the relationship between the polygenic risk score (PRS) obtained from a...

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PMID: 32573093
DOI: 10.1111/gbb.12683

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