Article
The functional serotonin 1a receptor promoter polymorphism, rs6295, is associated with psychiatric illness and differences in transcription.
Translational psychiatry - 1 Mar 2016
Donaldson Z R, le Francois B, Santos T L, Almli L M, Boldrini M, Champagne F A, Arango V, Mann J J, Stockmeier C A, Galfalvy H, Albert P R, Ressler K J, Hen R
Abstract excerpt
The G/C single-nucleotide polymorphism in the serotonin 1a receptor promoter, rs6295, has previously been linked with depression, suicide and antidepressant responsiveness. In vitro studies suggest that rs6295 may have functional effects on the expression of the serotonin 1a receptor gene (HTR1A) through altered binding of a number of transcription factors. To further explore the relationship between rs6295,...
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