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Article

Multiple regulatory variants modulate expression of 5-hydroxytryptamine 2A receptors in human cortex.

Biological psychiatry - 15 Mar 2013

Smith Ryan M, Papp Audrey C, Webb Amy, Ruble Cara L, Munsie Leanne M, Nisenbaum Laura K, Kleinman Joel E, Lipska Barbara K, Sadee Wolfgang

Abstract excerpt

BACKGROUND: The 5-hydroxytryptamine 2A receptor, encoded by HTR2A, is a major postsynaptic target for serotonin in the human brain and a therapeutic drug target. Despite hundreds of genetic associations investigating HTR2A polymorphisms in neuropsychiatric disorders and therapies, the role of genetic HTR2A variability in health and disease remains uncertain. METHODS: To discover and characterize regulatory HTR2A...

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Identifiers

PMID: 23158458
DOI: 10.1016/j.biopsych.2012.09.028
PMCID: PMC3582836

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