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Article

Epigenetic modification of PKMζ rescues aging-related cognitive impairment

1 Mar 2016

Abstract excerpt

Cognition is impacted by aging. However, the mechanisms that underlie aging-associated cognitive impairment are unclear. Here we showed that cognitive decline in aged rats was associated with changes in DNA methylation of protein kinase Mζ (PKMζ) in the prelimbic cortex (PrL). PKMζ is a crucial molecule involved in the maintenance of long-term memory. Using different behavioral models, we confirmed that aged rats...

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PMID: 26926225
DOI: 10.1038/srep22096

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