Effects of aging on spatial learning and hippocampal protein kinase C in mice.

Abstract excerpt

C57BL/6Nia and F1(B6xD2)Nia mice were tested on the Morris water maze task for 5 days followed by 12 days of testing on the place learning-set task (8 trials/day with each task). Mice were tested at 3, 14, and 25 months of age. C57 mice, 25 months of age, were significantly impaired in both the Morris and place learning-set task probe trial performance compared to mice 3 months of age (p < 0.05). These aged C57...

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