Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MK-801, a NMDA receptor antagonist, increases phosphorylation of histone H3 in the rat medial prefrontal cortex.

Pharmacological reports : PR - 1 Jan 2013

Maćkowiak Marzena, Guzik Rafał, Dudys Dorota, Bator Ewelina, Wędzony Krzysztof

Abstract excerpt

BACKGROUND: The present study investigated whether MK-801, when given in doses that cause psychomimetic effects in rats, could alter the phosphorylation of histone 3 (H3) at serine 10 (H3S10p) and the acetylation of H3 at lysine 14 (H3K14ac) in the medial prefrontal cortex (mPFC). These posttranslational modifications of H3 promote chromatin relaxation and increase the probability of gene expression. METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antipsychotic Agents
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dizocilpine Maleate

Share to Excitatory Amino Acid Antagonists

Share to Prefrontal Cortex

Share to Pyramidal Cells

Share to Receptors, N-Methyl-D-Aspartate

Share to Risperidone

Source

Identifiers

PMID: 24399707
DOI: 10.1016/s1734-1140(13)71469-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MK-801, a NMDA receptor antagonist, increases phosphorylation of histone H3 in the rat medial prefrontal cortex.PMID 24399707Read ↗

Kappa Opioid Receptor Activation Induces Epigenetic Silencing of Brain-Derived Neurotropic Factor via HDAC5 in DepressionSemantic proximity Read ↗

Kappa opioid receptor activation induces epigenetic silencing of brain-derived neurotropic factor via HDAC5 in depressionSemantic proximity Read ↗

Oral acetate supplementation attenuates N-methyl D-aspartate receptor hypofunction-induced behavioral phenotypes accompanied by restoration of acetyl-histone homeostasis.Semantic proximity Read ↗

Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibilitySemantic proximity Read ↗

Correlation between the epigenetic modification of histone H3K9 acetylation of NR2B gene promoter in rat hippocampus and ethanol withdrawal syndromeSemantic proximity Read ↗

An important role of the interplay between <i>Bdnf</i> transcription and histone acetylation in epileptogenesisSemantic proximity Read ↗

Propofol exposure during early gestation impairs learning and memory in rat offspring by inhibiting the acetylation of histoneSemantic proximity Read ↗

The absence of 5-HT(1A) receptors has minor effects on dopamine but not serotonin release evoked by MK-801 in mice prefrontal cortex.Semantic proximity Read ↗

PSA-NCAM expression in the rat medial prefrontal cortex.Semantic proximity Read ↗

HDAC inhibitors as cognitive enhancers in fear, anxiety and trauma therapy: where do we stand?Semantic proximity Read ↗

An Essential Role for Histone Deacetylase 4 in Synaptic Plasticity and Memory FormationSemantic proximity Read ↗

Epigenetic modification of PKMζ rescues aging-related cognitive impairmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.