Article
Receptor tyrosine kinase fusions act as a significant alternative driver of the serrated pathway in colorectal cancer development.
The Journal of pathology - 1 May 2020
Chan Anthony W-H, Pan Yi, Tong Joanna H-M, Lung Raymond W-M, Kwan Johnny S-H, Chow Chit, Tin Edith K-Y, Chung Lau-Ying, Li Hui, Wong Shela S-Y, Chau Shuk-Ling, Chan Yuk Yu, Mak Tony W-C, Ng Simon Siu-Man, To Ka-Fai
Abstract excerpt
Serrated polyps are a clinically and molecularly heterogeneous group of lesions that can contribute to the development of colorectal cancers (CRCs). However, the molecular mechanism underlying the development of serrated lesions is still not well understood. Here, we combined multiple approaches to analyze the genetic alterations in 86 colorectal adenomas (including 35 sessile serrated lesions, 15 traditional...
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