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Article

Clinicopathologic and genetic characterization of traditional serrated adenomas of the colon.

American journal of clinical pathology - 1 Sept 2012

Fu Baojin, Yachida Shinichi, Morgan Richard, Zhong Yi, Montgomery Elizabeth A, Iacobuzio-Donahue Christine A

Abstract excerpt

Traditional serrated adenomas (TSAs) are a type of colorectal polyp with neoplastic potential. Immunohistochemical analysis and sequencing were performed on 24 TSAs from 23 patients to characterize the molecular genetics of TSAs. Abnormal Ki-67 and p53 labeling were observed in 7 (29%) of 24 and 6 (25%) of 24 TSAs, respectively; both types were significantly associated with the presence of conventional epithelial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22912351
DOI: 10.1309/AJCPVT7LC4CRPZSK
PMCID: PMC3556914

Genes

BRAF
KRAS

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