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Article

Imputing Variants in HLA-DR Beta Genes Reveals That HLA-DRB1 Is Solely Associated with Rheumatoid Arthritis and Systemic Lupus Erythematosus.

PloS one - 1 Jan 2016

Kim Kwangwoo, Bang So-Young, Yoo Dae Hyun, Cho Soo-Kyung, Choi Chan-Bum, Sung Yoon-Kyoung, Kim Tae-Hwan, Jun Jae-Bum, Kang Young Mo, Suh Chang-Hee, Shim Seung-Cheol, Lee Shin-Seok, Lee Jisoo, Chung Won Tae, Kim Seong-Kyu, Choe Jung-Yoon, Nath Swapan K, Lee Hye-Soon, Bae Sang-Cheol

Abstract excerpt

The genetic association of HLA-DRB1 with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is well documented, but association with other HLA-DR beta genes (HLA-DRB3, HLA-DRB4 and HLA-DRB5) has not been thoroughly studied, despite their similar functions and chromosomal positions. We examined variants in all functional HLA-DR beta genes in RA and SLE patients and controls, down to the amino-acid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26919467
DOI: 10.1371/journal.pone.0150283
PMCID: PMC4769216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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