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Article

Subclinical generation of acyclovir-resistant herpes simplex virus with mutation of homopolymeric guanosine strings during acyclovir therapy.

Journal of dermatological science - 1 Jun 2016

Daikoku Tohru, Tannai Hidenori, Honda Mariko, Onoe Tomohiko, Matsuo Koma, Onoye Yasuhiko, Nishizawa Mika, Kawana Takashi, Okuda Tomoko, Hasegawa Tomomi, Shiraki Kimiyasu

Abstract excerpt

BACKGROUND: Suppressive therapy in patients with genital herpes has been used in Japan since 2006. Susceptibility and resistance of herpes simplex virus (HSV)-2 to acyclovir were examined in genital isolates from patients receiving suppressive therapy and compared with those from those naïve to acyclovir and receiving episodic treatment with acyclovir. OBJECTIVE: The aim of this study was to analyze the effect of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 26917345
DOI: 10.1016/j.jdermsci.2016.02.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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