Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Improvement of refractory acyclovir-resistant herpes simplex virus type 1 infection by continuous acyclovir administration.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 1 Jan 2019

Ikawa Yasuhiro, Fujiki Toshihiro, Nishimura Ryosei, Noguchi Kazuhiro, Koshino Eri, Fujiki Akiko, Fukuda Masaki, Kuroda Rie, Mase Shintaro, Araki Raita, Maeba Hideaki, Shiraki Kimiyasu, Yachie Akihiro

Abstract excerpt

Resistant herpes simplex virus type 1 (HSV-1) infection is sometimes fatal for immunocompromised patients. Here, we report 10-year-old girl receiving hematopoietic stem cell transplantation developed refractory HSV-1 infection, which was persisted to intermittent acyclovir (ACV) or foscarnet (FOS) administrations but was improved by continuous ACV administration. The isolates from the lesion were identified with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyclovir
Share to Foscarnet

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cell Transplantation

Share to Herpes Simplex

Share to Herpesvirus 1, Human

Share to Infusions, Intravenous

Share to Leukemia, Monocytic, Acute

Source

Identifiers

PMID: 30064949
DOI: 10.1016/j.jiac.2018.07.004

Genes

FOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Improvement of refractory acyclovir-resistant herpes simplex virus type 1 infection by continuous acyclovir administration.PMID 30064949Read ↗

Resistance of herpes simplex viruses to acyclovir: an update from a ten-year survey in France.Semantic proximity Read ↗

Phenotypic and genotypic characterization of acyclovir-resistant herpes simplex viruses from immunocompromised patients.Semantic proximity Read ↗

High prevalence but low clinical impact of acyclovir-resistant herpes simplex virus type 1 infections in patients with hematologic disorders.Semantic proximity Read ↗

Sequence Analysis of Herpes Simplex Virus 1 Thymidine Kinase and DNA Polymerase Genes from over 300 Clinical Isolates from 1973 to 2014 Finds Novel Mutations That May Be Relevant for Development of Antiviral Resistance.Semantic proximity Read ↗

"The end of innocence" revisited: resistance of herpesviruses to antiviral drugs.Semantic proximity Read ↗

Characterization of DNA polymerase-associated acyclovir-resistant herpes simplex virus type 1: mutations, sensitivity to antiviral compounds, neurovirulence, and in-vivo sensitivity to treatment.Semantic proximity Read ↗

Identification and characterization of acyclovir-resistant clinical HSV-1 isolates from children.Semantic proximity Read ↗

Acyclovir-resistant HSV-1 isolates among immunocompromised patients in southern Taiwan: Low prevalence and novel mutations.Semantic proximity Read ↗

Surveillance of herpes simplex virus resistance to antivirals: a 4-year survey.Semantic proximity Read ↗

Sequential switching of DNA polymerase and thymidine kinase-mediated HSV-1 drug resistance in an immunocompromised child.Semantic proximity Read ↗

Subclinical generation of acyclovir-resistant herpes simplex virus with mutation of homopolymeric guanosine strings during acyclovir therapy.Semantic proximity Read ↗

Resistance testing of clinical herpes simplex virus type 2 isolates collected over 4 decades.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.