Article
Current understanding and management of pulmonary Langerhans cell histiocytosis.
Thorax - 1 Oct 2017
Vassallo Robert, Harari Sergio, Tazi Abdellatif
Abstract excerpt
Pulmonary Langerhans cell histiocytosis (PLCH) is a diffuse lung disease that usually affects young adult smokers. PLCH affects different lung compartments; bronchiolar, interstitial and pulmonary vascular dysfunction may coexist to varying extents, resulting in diverse phenotypes. Analyses of PLCH tissues have identified activating mutations of specific mitogen-activated protein kinases (BRAFV600E and others)....
Topics
- Disease Progression
- Histiocytosis, Langerhans-Cell
- Humans
- Lung Diseases
- Phenotype
- Smoking