Article
Translating Lung Function Genome-Wide Association Study (GWAS) Findings: New Insights for Lung Biology.
Advances in genetics - 1 Jan 2016
Kheirallah A K, Miller S, Hall I P, Sayers I
Abstract excerpt
Chronic respiratory diseases are a major cause of worldwide mortality and morbidity. Although hereditary severe deficiency of α1 antitrypsin (A1AD) has been established to cause emphysema, A1AD accounts for only ∼ 1% of Chronic Obstructive Pulmonary Disease (COPD) cases. Genome-wide association studies (GWAS) have been successful at detecting multiple loci harboring variants predicting the variation in lung...
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