Article
Integrative pathway genomics of lung function and airflow obstruction.
Human molecular genetics - 1 Dec 2015
Gharib Sina A, Loth Daan W, Soler Artigas María, Birkland Timothy P, Wilk Jemma B, Wain Louise V, Brody Jennifer A, Obeidat Ma'en, Hancock Dana B, Tang Wenbo, Rawal Rajesh, Boezen H Marike, Imboden Medea, Huffman Jennifer E, Lahousse Lies, Alves Alexessander C, Manichaikul Ani, Hui Jennie, Morrison Alanna C, Ramasamy Adaikalavan, Smith Albert Vernon, Gudnason Vilmundur, Surakka Ida, Vitart Veronique, Evans David M, Strachan David P, Deary Ian J, Hofman Albert, Gläser Sven, Wilson James F, North Kari E, Zhao Jing Hua, Heckbert Susan R, Jarvis Deborah L, Probst-Hensch Nicole, Schulz Holger, Barr R Graham, Jarvelin Marjo-Riitta, O'Connor George T, Kähönen Mika, Cassano Patricia A, Hysi Pirro G, Dupuis Josée, Hayward Caroline, Psaty Bruce M, Hall Ian P, Parks William C, Tobin Martin D, London Stephanie J
Abstract excerpt
Chronic respiratory disorders are important contributors to the global burden of disease. Genome-wide association studies (GWASs) of lung function measures have identified several trait-associated loci, but explain only a modest portion of the phenotypic variability. We postulated that integrating pathway-based methods with GWASs of pulmonary function and airflow obstruction would identify a broader repertoire of...
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