[Misfolded proteins complexed with HLA class II molecules are involved in autoimmune diseases as a target for autoantibodies].

Abstract excerpt

HLA class II molecules play an important role in immune response by presenting peptide antigens to T cells. However, when misfolded proteins in endoplasmic reticulum, which are generally degraded in the cells, are associated with MHC class II molecules instead of invariant chain, the misfolded proteins are transported to the cell surface without processing to peptides. Furthermore, misfolded proteins associated...

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