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β2-Glycoprotein I/HLA class II complexes are novel autoantigens in antiphospholipid syndrome

3 Mar 2015

Abstract excerpt

Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by thrombosis and/or pregnancy complications. β2-glycoprotein I (β2GPI) complexed with phospholipid is recognized as a major target for autoantibodies in APS; however, less than half the patients with clinical manifestations of APS possess autoantibodies against the complexes. Therefore, the range of autoantigens involved in APS remains...

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PMID: 25733579
DOI: 10.1182/blood-2014-08-593624

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