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Article

Role of F357 as an Oxygen Gate in the Oxidative Half-Reaction of Choline Oxidase.

Biochemistry - 15 Mar 2016

Salvi Francesca, Rodriguez Isela, Hamelberg Donald, Gadda Giovanni

Abstract excerpt

Choline oxidase from Arthrobacter globiformis catalyzes the oxidation of choline to glycine betaine by using oxygen as an electron acceptor. A partially rate limiting isomerization of the reduced wild-type enzyme during the reaction with oxygen was previously detected using solvent viscosity effects. In this study, we hypothesized that the side chains of M62 and F357, located at the entrance to the active site of...

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Identifiers

PMID: 26907558
DOI: 10.1021/acs.biochem.5b01356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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