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Article

Genetic editing of HLA expression in hematopoietic stem cells to broaden their human application.

Scientific reports - 23 Feb 2016

Torikai Hiroki, Mi Tiejuan, Gragert Loren, Maiers Martin, Najjar Amer, Ang Sonny, Maiti Sourindra, Dai Jianliang, Switzer Kirsten C, Huls Helen, Dulay Gladys P, Reik Andreas, Rebar Edward J, Holmes Michael C, Gregory Philip D, Champlin Richard E, Shpall Elizabeth J, Cooper Laurence J N

Abstract excerpt

Mismatch of human leukocyte antigens (HLA) adversely impacts the outcome of patients after allogeneic hematopoietic stem-cell transplantation (alloHSCT). This translates into the clinical requirement to timely identify suitable HLA-matched donors which in turn curtails the chances of recipients, especially those from a racial minority, to successfully undergo alloHSCT. We thus sought to broaden the existing pool...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26902653
DOI: 10.1038/srep21757
PMCID: PMC4763194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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