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Article

HLA-Knockout: Enabling Allele-Specific Knockout of HLA Class I Genes for Immunogenic Engineering.

HLA - 1 Jan 2026

Mattivi Connor, Wang Shiyu, Ji Longtao, Xiao Qian, Cao Jian

Abstract excerpt

The interaction between T-cell receptors (TCRs) and antigenic peptides presented by HLA molecules is fundamental to adaptive immunity. However, the extreme polymorphism of HLA genes poses major challenges for transplantation, antigen discovery, immunotherapy and studies of allele-specific function. Although CRISPR/Cas9 has transformed gene editing, existing sgRNA design tools are not optimised for knockout of HLA...

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PMID: 41562237
DOI: 10.1111/tan.70548
PMCID: PMC12820913

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PAM

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