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Genome editing HLA alleles for a pilot immunocompatible hESC line in a Chinese hESC bank for cell therapies.

Cell proliferation - 1 May 2023

Ji Tian-Tian, Niu Shuai-Shuai, Fang Ming-Hui, Xu Ling-Xue, Wang Xin, Zou Jun, Xu Fei, Zhang Meng, Niu Rui, Wu Jun, Wang Lei, Li Zhi-Kun, Yang Yong-Guang, Hao Jie, Li Wei, Hu Zheng, Zhou Qi

Abstract excerpt

Robust allogeneic immune reactions after transplantation impede the translational pace of human embryonic stem cells (hESCs)-based therapies. Selective genetic editing of human leucocyte antigen (HLA) molecules has been proposed to generate hESCs with immunocompatibility, which, however, has not been specifically designed for the Chinese population yet. Herein, we explored the possibility of customizing...

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Identifiers

PMID: 37199039
DOI: 10.1111/cpr.13471
PMCID: PMC10212709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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