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Current status and future perspectives of HLA-edited induced pluripotent stem cells

1 Oct 2020

Abstract excerpt

In 2007, Human-induced pluripotent stem cells (iPSCs) were generated by transducing four genes (Oct3/4, Sox2, Klf4, c-Myc). Because iPSCs can differentiate into any types of cells in the body and have fewer ethical issues compared to embryonic stem (ES) cells, application of iPSCs for regenerative medicine has been actively examined. In fact, iPSCs have already been used for clinical applications, but at present,...

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PMID: 33014207
DOI: 10.1186/s41232-020-00132-9

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