Article
Different polymorphisms of the mineralocorticoid receptor gene are associated with either glucocorticoid or mineralocorticoid levels in hypertension.
The Journal of clinical endocrinology and metabolism - 1 Sept 2012
Sun Bei, Chamarthi Bindu, Williams Jonathan S, Krug Alexander W, Lasky-Su Jessica, Raby Benjamin A, Hopkins Paul N, Jeunemaitre Xavier, Ferri Claudio, Williams Gordon H
Abstract excerpt
OBJECTIVE: Both aldosterone and cortisol can activate the mineralocorticoid receptor (MR). Polymorphisms in the MR gene have been inconsistently shown to be associated with risk of hypertension and aldosterone and cortisol levels. The purpose of this project was to investigate the association of MR gene variants with serum aldosterone and a previously identified hypertension subgroup with higher urinary free...
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