Article
Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.
The Journal of clinical endocrinology and metabolism - 1 Feb 2005
Keavney Bernard, Mayosi Bongani, Gaukrodger Nicole, Imrie Helen, Baker Michelle, Fraser Robert, Ingram Mary, Watkins Hugh, Farrall Martin, Davies Eleanor, Connell John
Abstract excerpt
Genetic variation in the gene encoding aldosterone synthase (CYP11B2) has previously been shown to be associated with hypertension and left ventricular hypertrophy. The intermediate phenotype most consistently associated with variation at this locus is that of elevated plasma 11-deoxycortisol (S)...
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