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CYP17A1 Locus: Regulatory Mechanisms and Clinical Associations With Cardiovascular Disease and Metabolic Syndrome.

IUBMB life - 1 Apr 2026

Chakkor Yasmine, Aherrahrou Redouane

Abstract excerpt

The CYP17A1 gene encodes the P450 17α-hydroxylase/17,20-lyase protein, a key enzyme in steroidogenesis. In the past, it was associated with disorders such as congenital adrenal hyperplasia, disorders of sex development, and castration resistant prostate cancer. Recently, genome-wide association studies have revealed that the locus harboring the CYP17A1 gene is strongly associated with multiple other traits,...

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Identifiers

PMID: 41930574
DOI: 10.1002/iub.70096

Genes

CYP17A1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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