Article
C-terminal Src Kinase Gates Homeostatic Synaptic Plasticity and Regulates Fasciclin II Expression at the Drosophila Neuromuscular Junction.
PLoS genetics - 1 Feb 2016
Spring Ashlyn M, Brusich Douglas J, Frank C Andrew
Abstract excerpt
Forms of homeostatic plasticity stabilize neuronal outputs and promote physiologically favorable synapse function. A well-studied homeostatic system operates at the Drosophila melanogaster larval neuromuscular junction (NMJ). At the NMJ, impairment of postsynaptic glutamate receptor activity is offset by a compensatory increase in presynaptic neurotransmitter release. We aim to elucidate how this process operates...
Topics
- Animals
- Animals, Genetically Modified
- CSK Tyrosine-Protein Kinase
- Cell Adhesion Molecules, Neuronal
- Drosophila Proteins
- Drosophila melanogaster
- Homeostasis
- Mutation
- Neuroglia
- Neuromuscular Junction
- Neuronal Plasticity
- Protein Isoforms
- Synaptic Transmission
- src-Family Kinases