Article
A Glutamate Homeostat Controls the Presynaptic Inhibition of Neurotransmitter Release.
Cell reports - 8 May 2018
Li Xiling, Goel Pragya, Wondolowski Joyce, Paluch Jeremy, Dickman Dion
Abstract excerpt
We have interrogated the synaptic dialog that enables the bi-directional, homeostatic control of presynaptic efficacy at the glutamatergic Drosophila neuromuscular junction (NMJ). We find that homeostatic depression and potentiation use disparate genetic, induction, and expression mechanisms. Specifically, homeostatic potentiation is achieved through reduced CaMKII activity postsynaptically and increased...
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